Document 0640
 DOCN  M9480640
 TI    High mortality among HIV-infected injecting drug users without AIDS
       diagnosis: implications for HIV infection epidemic modellers?
 DT    9410
 AU    van Haastrecht HJ; van den Hoek AJ; Coutinho RA; Municipal Health
       Service, Department of Public Health and; Environment, Amsterdam, The
       Netherlands.
 SO    AIDS. 1994 Mar;8(3):363-6. Unique Identifier : AIDSLINE MED/94304558
 AB    OBJECTIVE: To quantify mortality without AIDS diagnosis (pre-AIDS death)
       among HIV-infected injecting drug users (IDU) and to compare it with
       that among homosexual men. SETTING: Municipal Health Service in
       Amsterdam, The Netherlands. DESIGN: HIV-infected participants of a
       cohort of homosexual men (recruited since 1984) and a cohort of IDU
       (recruited since 1985) were followed up to investigate the occurrence of
       AIDS and pre-AIDS death up to 1 October 1992. Both seroprevalent and
       seroconverted participants were included. METHODS: Product-limit
       estimates of cumulative AIDS incidence and cumulative pre-AIDS mortality
       were calculated for a competing risks model. RESULTS: Of 455
       HIV-infected homosexual men, 127 developed AIDS and two died without a
       diagnosis of AIDS during follow-up; 31 out of 279 HIV-infected IDU were
       diagnosed with AIDS and 33 died without an AIDS diagnosis. After 6.5
       years of follow-up an estimated 43.7% of the homosexual men had been
       diagnosed with AIDS and 0.7% had died without an AIDS diagnosis, while
       32.7% of the IDU had been diagnosed with AIDS and 19.8% had died without
       an AIDS diagnosis. CONCLUSIONS: After 6.5 years of follow-up one-fifth
       of a group of HIV-infected IDU had died without being diagnosed with
       AIDS. This phenomenon seriously limits the number of HIV-infected IDU
       that may ever be diagnosed with AIDS and should be considered by HIV
       infection epidemic modellers. The new case definitions for AIDS will
       limit the number of recorded cases of pre-AIDS death.
 DE    Acquired Immunodeficiency Syndrome/COMPLICATIONS/DIAGNOSIS/  MORTALITY
       Adult  Cohort Studies  *Disease Outbreaks/STATISTICS & NUMER DATA
       Female  Follow-Up Studies  Human  HIV
       Infections/*COMPLICATIONS/*MORTALITY  Male  Middle Age  *Models,
       Biological  Netherlands/EPIDEMIOLOGY  Substance Abuse,
       Intravenous/*COMPLICATIONS/*MORTALITY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).